产品货号：
Z21830
中文名称：
NPC1L1抗体
英文名称：
Anti-NPC1L1 Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-NPC1L1 Antibody |
| 指标别名 | NPC1L1;NPC1-like intracellular cholesterol transporter 1;Niemann-Pick C1-like protein 1 |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB,ICC/IF,FCM,ELISA |
| 基因名称 | NPC1L1 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | E.coli-derived human Niemann Pick C1 Like 1/NPC1L1 recombinant protein (Position:L778-A1231). |
| 实际分子量 | 149KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | Niemann-Pick C1-Like 1 (NPC1L1) is a protein found on the gastrointestinal tract epithelial cells as well as in hepatocytes.The protein encoded by this gene is a multi-pass membrane protein.It contains a conserved N-terminal Niemann-Pick C1 (NPC1) domain and a putative sterol-sensing domain (SSD) which includes a YQRL motif functioning as a plasma membrane to trans-Golgi network transport signal in other proteins.This protein takes up free cholesterol into cells through vesicular endocytosis and plays a critical role in the absorption of intestinal cholesterol.It also has the ability to transport alpha-tocopherol (vitamin E).The drug ezetimibe targets this protein and inhibits the absorption of intestinal cholesterol and alpha-tocopherol.In addition,this protein may play a critical role in regulating lipid metabolism.Polymorphic variations in this gene are associated with plasma total cholesterol and low-density lipoprotein cholesterol (LDL-C) levels and coronary heart disease (CHD) risk.Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
| Uniprot ID | Q9UHC9 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot. |
| 基因名全称 | NPC1 like intracellular cholesterol transporter 1 |
| 蛋白名全称 | NPC1-like intracellular cholesterol transporter 1 |
| 推荐稀释比 | Western blot(WB) 1:500～2000 Immunocytochemistry/Immunofluorescence (ICC/IF) 1:50～400 Flow cytometry (FCM) 1～3μg/1×106 cells ELISA 1:100～1000 |
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